Statins not only extend life by lowering cholesterol level and reducing the risks of cardiovascular disease: research suggests that they may extend lifespan as well. Specifically, statins may reduce the rate at which telomeres shorten, a key factor in the natural aging process. This opens the door for using statins, or derivatives of statins, as an anti-aging therapy.
“By telomerase activation, statins may represent a new molecular switch able to slow down senescent cells in our tissues and be able to lead healthy lifespan extension,” said Giuseppe Paolisso, M.D., Ph.D., a researcher involved in the work from the Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine at Second University of Naples in Italy.
Paolisso and colleagues worked with two groups of subjects. The first group was under chronic statin therapy, and the second group (control), did not use statins. When researchers measured telomerase activity in both groups, those undergoing statin treatment had higher telomerase activity in their white blood cells, which was associated with lower telomeres shortening along with aging as compared to the control group. This strongly highlights the role of telomerase activation in preventing the excessive accumulation of short telomeres.
“The great thing about statins is that they reduce risks for cardiovascular disease significantly and are generally safe for most people,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. “But if it is confirmed that statins might actually slow aging itself – and not just the symptoms of aging – then statins are much more powerful drugs than we ever thought.”