Telomerase Activators – one more attempt to find anti-aging pill

Discovering mechanisms for increasing the length of telomeres gives us great hope to slow aging and prevent cancer. Short telomeres is premature aging and low life expectancy. It means, the activator is needed that restores telomere length by telomerase activation.

The telomerase activating agents TA-65, cycloastragenol and astragaloside IV show huge anti-aging potential in adult and old mice due to significant telomerase Lengthening.

The biomedical research journal Aging Cell recently published a study entitled: “Telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence”. The research adds to the growing evidence that TA-65 can lengthen very short telomeres and extend the healthy portion of lifespan as indicated by measurements collected including glucose tolerance, insulin sensitivity, osteoporosis, and skin condition.
Another recent study showed that astragalus root (Chinses herb) compound reverses telomere loss in immune cells. Like other kinds of cells, immune cells lose their ability to divide over time as the telomeres on their chromosomes become progressively shorter with each cell division. As a result, the disease-fighting ability of immune cells becomes compromised with age. In the new study, the team at UCLA found that the compound, cycloastragenol, derived from Chinese Astragalus root, can prevent or slow the progressive loss of telomeres in key immune cells, potentially making it a key weapon in the fight against HIV and other viral diseases.

Telomere lengthening will one day be regarded as one major component in workable anti-aging medicine for the masses.  Unfortunately, at present TA-65 is still very expensive. But luckily we know what are main ingredients of TA-65 – they are Cycloastrogenol and Astragaloside IV. These two key substances can be bought in Europe with prices 2-3 times cheaper than TA-65 itself.

These two Chinese herb-derived small molecule telomerase activators astragaloside IV (AG-IV) and cycloastragenol (CAG), main ingredients of TA-65 have recently been shown to improve the proliferative response of CD8+ T lymphocytes from HIV-infected patients by upregulating telomerase activity. Telomerase activity in human embryonic kidney HEK293 fibroblasts was increased upon treatment with increasing concentrations of AG-IV or CAG. Both compounds induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) in a time- and dose-dependent manner in HEK293 cells and HEK-neo keratinocytes. AG-IV and CAG also stimulated ERK phosphorylation in other cell lines of lung, brain, mammary, endothelial, and hematopoietic origins. Use of selective inhibitors and dominant negative mutants revealed the involvement of c-Src, MEK (ERK kinase), and epidermal growth factor receptor in CAG-induced ERK phosphorylation. Our data indicate that AG-IV and CAG may exert their cellular effects through the activation of the Src/MEK/ERK pathway.

More information about TA-65, cycloastragenol and astragaloside IV

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