- Do not use Celebrex if you have any known hypersensitivity reactions to celecoxib or sulphonamides.
- Do not use Celebrex if you have a history of allergic reactions to aspirin or other NSAIDs (including asthma andurticaria).
- Do not use Celebrex during the perioperative period in the setting of coronary artery bypass graft (CABG) surgery.
- Patients with known cardiovascular (CV) disease(s) should use with caution.
- Patients with history of gastrointestinal (GI) bleeding, ulcer disease(s), or other GI-related conditions, and especially the elderly, should use with caution.
- Avoid or use with care if you are already taking any of the drugs described in the Drug Interactions section.
- Hypertensive patients should monitor their blood pressure frequently while taking Celebrex.
- Patients with heart failure, impaired renal function, fluid retention or liver dysfunction should use with caution.
- The elderlyshould use with caution.
- Discontinue use of Celebrex with the first signs of rash or skin reactions.
Side Effects/Adverse ReactionS:
Serious cardiovascular events (including thrombosis, myocardial infarction, stroke).
Serious gastrointestinal events.
Liver events (rarely serious) including elevated liver enzymes.
Hypertension (onset or worsening of existing one).
Fluid retention that can lead tooedema.
Renal injuries such as renal papillary necrosis.
Anaphylaxis (allergic reactions).
Serious skin events.
In arthritis patients, the following were sometimes observed: rash, abdominal pain, dyspepsia, diarrhoea, flatulence, peripheral oedema, rhinitis, pharyngitis,sinusitis and upper respiratory tract infection. About dosage and Drug Interactions read here http://www.lifespanmeds.com/celebrex.html .